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有机金化合物作为慢性风湿关节病的治疗剂被广泛应用于临床,而且,对于铅作业者的慢性风湿关节病注射金制剂而对关节痛的缓解有良好的治疗效果。可是,据报导这些金制剂可造成不可逆的造血障碍。甚至有时致死。另外,铅作用于血红素合成系统,抑制该系统的几种酶(ALA-D、铁导入酶)的活性,使红细胞游离原卟啉(FEP)、尿中粪卟啉(CP-U)及尿中δ-氨基乙酰丙酸(ALA-U)增加。因此对于铅中毒患者使用金制剂时,研究其对血红素代谢异常如何起作用是具有意义的。
Organometallic compounds have been widely used clinically as a therapeutic agent for chronic rheumatoid arthritis and have been shown to have a good therapeutic effect on the relief of joint pain in chronic rheumatoid arthritis patients injected with gold preparations. However, it is reported that these gold preparations can cause irreversible hematopoietic disorders. Even death sometimes. In addition, lead acts on the heme biosynthesis system and inhibits the activity of several enzymes in this system (ALA-D, iron-inducible enzyme), making erythrocyte free protoporphyrin (FEP), urinary fecal porphyrin Urinary δ-aminolevulinic acid (ALA-U) increased. Therefore, the use of gold preparations for patients with lead poisoning, the study of its hemoglobin metabolism of how the role of significance is meaningful.