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本文测定了国产环丙氟哌酸对临床分离的883株需氧菌与58株厌氧菌的抗菌作用。金葡球菌的 MIC_(90) 为1mg/L,除沙雷菌的 MIC_(90)为0.25mg/L外,其他肠杆菌科细菌的 MIC_(90)≤0.06mg/L,绿脓杆菌和不动杆菌属的 MIC_(90)分别为1mg/L和0.125～0.5mg/L,90％以上的耐Ceftazidime和庆大霉素的革兰氏阴性菌对环丙氟哌酸仍敏感。对淋球菌的MIC_(90)≤0.0075mg/L,环丙氟哌酸与氧哌嗪青霉素联合对绿脓杆菌和肠球菌、环丙氟哌酸与庆大霉素联合对耐甲氧西林金葡球菌50％呈协同和相加作用,均未出现拮抗现象。
The antibacterial activity of domestic ciprofloxacin against 883 strains of aerobic bacteria and 58 strains of anaerobic bacteria was determined in this paper. Staphylococcus aureus MIC_ (90) of 1mg / L, in addition to the Serratia MIC_ (90) 0.25mg / L, other Enterobacteriaceae MIC_ (90) ≤ 0.06mg / L, Pseudomonas aeruginosa and not Acinetobacter MIC_ (90) were 1mg / L and 0.125 ~ 0.5mg / L, more than 90% of Ceftazidime and gentamicin-resistant gram-negative bacteria are still sensitive to ciprofloxacin. For MIC0 (90) ≤0.0075mg / L for Neisseria gonorrhoeae, combination of Ciprofloxacin and piperacillin against Pseudomonas aeruginosa and enterococci, Ciprofloxacin and Gentamycin combined with methicillin- Staphylococcus aureus 50% showed a synergistic and additive effect, did not appear antagonistic phenomenon.