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1992年以来,我院应用山东省医药工业研究所生产的格列齐特片(GZ)治疗NIDDM中经过饮食加运动治疗仍未能良好控制的高血糖者,即空腹血糖≥7.8mmol/L(140mg/dl),餐后 2 小时血糖≥11.1mmol/ L(200mg/dl)者。对病情较轻、 > 60岁或有DM性视网膜病变、DM性肾病者,可优先考虑GZ。空腹血糖<16.7mmol/L (300mgdl)者,可单用本药或其他SU,一般空腹血糖<12.2mmol/L(220mg/dl)时疗效较佳。如空腹血糖轻度增高或糖尿病症状不明显,可从40mg/d开始,早餐前服用,每3～5天根据前一日血、尿糖及有无低血糖表现调整一次剂量,每次约增减40mg。如血糖明显增高,且DM症状明显,则可从80mg/d开始,每5～7天调整一次剂量,如血糖仍控制不良,每次增加80mg。超过80mg时分早、晚两次餐前用,早餐前剂量应较大,至少与晚间剂量相等,最大量 240～320mg/d。当血糖获良好控制后可逐渐减量,每周1次。
Since 1992, our hospital application of gliclazide tablets (GZ) produced by the Institute of Pharmaceutical Industry in Shandong Province for the treatment of NIDDM diet and exercise are still not well controlled hyperglycemia who fasting blood glucose ≥ 7.8mmol / L ( 140mg / dl), 2 hours postprandial blood glucose ≥11.1mmol / L (200mg / dl) who. For mild disease,> 60 years old or have DM retinopathy, DM nephropathy, give priority to GZ. Fasting blood glucose <16.7mmol / L (300mgdl) who can be alone with the drug or other SU, general fasting blood glucose <12.2mmol / L (220mg / dl) when the curative effect is better. Such as mild or moderate fasting blood glucose increased symptoms of diabetes is not obvious, starting from 40mg / d, taking before breakfast, every 3 to 5 days according to the day before the blood, urine glucose and hypoglycemia with or without a dose adjustment, each about an increase Minus 40mg. Such as blood glucose was significantly higher, and DM symptoms were obvious, you can start from 80mg / d, every 5 to 7 days to adjust a dose, such as blood glucose is still poor control, each increase of 80mg. More than 80mg hours early and late meals before breakfast, the dose should be larger before breakfast, at least equal to the evening dose, the maximum amount of 240 ~ 320mg / d. When blood sugar is well controlled, it can be gradually reduced once a week.