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为探讨妊娠肝内胆汁瘀积症（ＩＣＰ）对母儿的影响，对１９８９～１９９６年在我院住院分娩的４７１例ＩＣＰ患者的症状、肝功及妊娠结局进行了回顾性分析。结果：搔痒出现孕周平均３２．４±４．７周（１２～４０周）；早产率１６．６％（７８例）；围产儿死亡率１２．７‰（６例）；羊水Ⅱ°～Ⅲ°１１４例（２４．２％）；分娩方式（自然产＝１，阴道助产＝２，剖宫产＝３）与新生儿Ａｐｇａｒ评分呈正相关（ｒ＝０．１１８８，Ｐ＜０．０５）；３０～３３＋６周组羊水性状明显比３７周组差（０．８９±１．１１比０．５５±０．９６，Ｐ＜０．０５）；血总胆红素＞３４μｍｏｌ／Ｌ组羊水性状明显比１７．１～３４μｍｏｌ／Ｌ组差（０．９６±１．１１比０．６５±１．０４，Ｐ＜０．０５）；血总胆汁酸＞４０μｍｏｌ／Ｌ组羊水性状比正常组（≤２０μｍｏｌ／Ｌ）差（０．８９±１．１比０．３３±０．８８，Ｐ＜０．０５）。由此提示：搔痒出现孕周的提前（３０～３６＋６周）、血总胆红素及总胆汁酸的增加可作为ＩＣＰ程度划分的指标，适时的剖宫产可以提高新生儿Ａｐｇａｒ评分。
To investigate the influence of intrahepatic cholestasis of pregnancy (ICP) on maternal and childbirth, the symptoms, liver function and pregnancy outcome of 471 ICP patients hospitalized in our hospital from 1989 to 1996 were analyzed retrospectively. Results: The average incidence of itch was 32.4 ± 4.7 weeks (12 ~ 40 weeks), premature delivery rate was 16.6% (78 cases), perinatal mortality rate was 12.7% (6 cases), amniotic fluid Ⅱ ° ~ Ⅲ ° 114 cases (24.2%). There was a positive correlation between neonatal Apgar score and delivery mode (n = 1, vaginal delivery = 2, cesarean section = 3) ). The amniotic fluid in 30 ~ 33 + 6 weeks group was significantly worse than that in 37 weeks group (0.89 ± 1.11 vs 0.55 ± 0.96, P <0.05) The trait was significantly worse than that of 17.1 ~ 34μmol / L group (0.96 ± 1.11 vs 0.65 ± 1.04, P <0.05) (≤20μmol / L) difference (0.89 ± 1.1 vs 0.33 ± 0.88, P <0.05). This prompted: Itchy gestational weeks ahead of (30 ~ 36 +6 weeks), total blood bilirubin and total bile acid increase can be used as an index of the degree of ICP, timely cesarean section can improve neonatal Apgar score.