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目的 探讨肝动脉化学栓塞 (TAE)加局部高温固化治疗人体大肝癌的临床效果。方法 采用介入疗法先行TAE后 ,局部高温固化肝肿瘤并行直视下手术切除。结果 追踪随访 5年 ,32例大肝癌病人中 1年生存者 2 5例 ,3年生存者 12例 ,5年生存者 6例 ;其生存率分别为 78.0 %、37.5 %、18.7%,术中及术后无明显并发症。结论 TAE使大肝癌缩小 ,然后行局部高温固化一期完整切除 ,其优点 :减少出血量、降低手术危险性、完整切除肿瘤 ,避免单纯高温固化有深部肿瘤的残余。术后再行TAE ,这样基本达到临床根治目的 ,延长病人寿命 ,提高生存率 ,临床疗效满意。
Objective To investigate the clinical effect of transcatheter arterial chemoembolization (TAE) plus local hyperthermia on human large hepatocellular carcinoma. Methods TAE after interventional therapy was performed. Local high temperature solidified liver tumor was operated under direct vision. Results The follow-up was 5 years. Twenty-five patients with large hepatocellular carcinoma (HCC) had 1-year survival in 25 cases, 3-year survival in 12 cases and 5-year survival in 6 cases. The survival rates were 78.0%, 37.5%, 18.7% No postoperative complications were found. Conclusions TAE can reduce large hepatocellularcarcinoma and then complete local resection with local hyperthermia. The advantages are: to reduce the amount of bleeding, reduce the risk of operation, complete resection of the tumor and avoid the remnants of deep tumor solidified by high temperature. TAE after surgery, so basically to achieve the purpose of clinical cure, extend patient life expectancy, improve survival, clinical efficacy satisfactory.