近年来国外对肝衰竭的发病机制以及与之有关的动物模型进行了许多研究,并获得可喜的进展,现扼要介绍如下。发病机制方面的研究进展有关氨和氨基酸(amino acid,AA)与肝昏迷关系的研究Bockel 针对有人提出血氨与肝昏迷无关的观点,重点研究了肝硬化上消化道出血后肝昏迷的发病机制,特别是血氨及血 AA 与肝昏迷的关系。28例肝硬化上消化道出血后肝昏迷患者(出血均经三腔管控制),随机分成2组:一组用甘露醇经三腔管清洗消化道(治疗 In recent years, many studies on the pathogenesis of liver failure and animal models related to it have been made abroad, and some encouraging progress have been made. Pathogenesis Research progress on the relationship between ammonia and amino acids (AA) and hepatic coma Bockel Some people put forward the view that blood ammonia has nothing to do with hepatic coma, focusing on the pathogenesis of hepatic coma after cirrhosis and upper gastrointestinal bleeding , Especially blood ammonia and blood AA and hepatic coma relationship. Twenty-eight hepatic cirrhosis patients with hepatic coma after hemorrhagic upper gastrointestinal bleeding (bleeding were controlled by the three-lumen tube) were randomly divided into two groups: a group of mannitol through the three-lumen tube to clean the digestive tract (treatment