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目的探讨组织因子途径抑制剂2(TFPI-2)在胃癌中表达的临床意义及其预后分析。方法选取2011年12月至2012年12月间入院进行手术治疗的64例胃癌患者的石蜡切片标本,采用免疫组织化学方法检测标本中TFPI-2的蛋白表达情况。结果胃正常黏膜组织中TFPI-2的阳性表达率为71.9%,胃癌组织中TFPI-2的阳性表达率为43.8%;无淋巴结转移的TFPI-2阳性表达率为75.0%,淋巴结转移的TFPI-2阳性表达率为25.0%;无浆膜浸润的TFPI-2阳性表达率为83.3%,有浆膜浸润的TFPI-2阳性表达率为28.3%,以上差异均有统计学意义(均P<0.05)。TFPI-2的表达与年龄、性别、肿瘤大小、肿瘤部位和组织类型无显著相关性(P>0.05),但与分化程度、浆膜浸润、淋巴结转移和TNM分期相关(P<0.05)。另外,TFPI-2低表达患者的预后较差。结论胃癌患者中TFPI-2的低表达与临床病理特征具有一定相关性,通过检测TFPI-2的表达可以预测患者预后。
Objective To investigate the clinical significance and prognosis of tissue factor pathway inhibitor 2 (TFPI-2) in gastric cancer. Methods Sixty-six paraffin-embedded specimens of patients with gastric cancer admitted to our hospital from December 2011 to December 2012 were enrolled in this study. Immunohistochemistry was used to detect the protein expression of TFPI-2 in the specimens. Results The positive rate of TFPI-2 in gastric normal mucosa was 71.9%, while the positive rate of TFPI-2 in gastric cancer was 43.8%. The positive rate of TFPI-2 without lymph node metastasis was 75.0% 2 positive expression rate was 25.0%. The positive expression rate of TFPI-2 without serosal invasion was 83.3% and the positive rate of serosal infiltration TFPI-2 was 28.3% (all P <0.05 ). There was no significant correlation between TFPI-2 expression and age, sex, tumor size, tumor location and type of tissue (P> 0.05), but correlated with differentiation degree, serosal invasion, lymph node metastasis and TNM staging (P <0.05). In addition, patients with low TFPI-2 expression have a poor prognosis. Conclusion The low expression of TFPI-2 in gastric cancer patients has a certain correlation with clinicopathological features. The prognosis of patients can be predicted by detecting the expression of TFPI-2.