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本文作者用两种不同的方药来预防激素造成的家兔股骨头坏死。在接受12.25mg/kg 强的松龙的对照组动物。发现动物有进行性高血脂,股骨头内的骨细胞空泡变和坏死,脂肪细胞膨大,骨小梁变细,毛细血管扩张和骨内压增高。同时,动物心、肝、肾、肺的细胞肿胀、变性甚至坏死。和对照组相比,中药骨通Ⅱ组的血清胆固醇和甘油三酯降低,骨细胞空泡变和坏死的百分率明显降低,P<0.01。同时发现骨小梁的横径较粗,脂肪细胞、毛细血管的病理改变较轻,骨内压也较低。骨通Ⅱ组的中药对内脏器官的细胞有明显的保护作用。骨通Ⅰ组的效果不如Ⅱ组,且有出血倾向。实验表明骨通Ⅱ组具有抗高血脂、预防类固醇激素造成的股骨头和内脏细胞坏死的作用。
The authors used two different prescriptions to prevent hormone-induced femoral head necrosis in rabbits. The control animals received 12.25 mg/kg prednisolone. Animals were found to have progressive hyperlipidemia, vacuoles and necrosis of bone cells in the femoral head, enlargement of fat cells, thinning of trabeculae, expansion of capillaries, and increased intraosseous pressure. At the same time, the cells of the animal heart, liver, kidneys, and lungs are swollen, degenerated or even necrotic. Compared with the control group, serum cholesterol and triglyceride in the Chinese medicine group Tongtong II decreased, and the percentage of bone cell vacuolation and necrosis decreased significantly, P<0.01. At the same time, it was found that the transverse diameter of the trabecular bone was thicker, and the pathological changes of fat cells and capillaries were lighter and the intraosseous pressure was also lower. The Tongtong II group’s traditional Chinese medicine has obvious protective effects on the internal organs of cells. The effect of bone-pass I group was not as good as that of group II, and there was a tendency to bleed. Experiments have shown that the Tongtong II group has anti-hyperlipidemia and prevents the necrosis of the femoral head and visceral cells caused by steroid hormones.