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超氧化物歧化酶(superoxide dismutase,简称SOD)是广泛存在于生物体内的一类金属酶。它具有催化超氧阴离子自由基(O_2~-)发生歧化反应的功能,凡由O_2~-引起的疾病,如炎症、放射病和免疫性疾病等均有较好的疗效。Huber等曾以不同注射途径(静注、肌注和皮下注射)给人和动物(小鼠、大鼠、豚鼠和狗)注射牛SOD,采用四氮唑蓝-核黄素染色酶谱法和放射免疫法研究其药物动力学。本实验给家兔和小鼠注射猪血SOD,采用极谱法测定
Superoxide dismutase (superoxide dismutase, referred to as SOD) is widely found in the body of a class of metalloenzyme. It has the function of catalyzing the disproportionation reaction of superoxide anion radical (O_2 ~). All the diseases caused by O_2 ~, such as inflammation, radiation sickness and immune diseases, have a good curative effect. Huber et al. Injected human cattle and animals (mice, rats, guinea pigs and dogs) with different injection routes (intravenous injection, intramuscular injection and subcutaneous injection) with SOD, using the method of tetrazolium blue-riboflavin staining Radioimmunoassay was used to study its pharmacokinetics. In this experiment, rabbit and mouse were injected with porcine blood SOD by polarography