吡哌酸(PPA)为一新型的全合成抗生素,1975年日本首先合成,1981年我国正式投产并应用于临床。实践表明,PPA对革兰氏阴性菌具有较好的抑菌和杀菌作用,应用范围越来越广,但临床发现其不良反应也越来越多,现结合我们所遇病例并复习有关文献,将其不良反应综述于下,供临床工作者参考。 Pipemidic acid (PPA) is a new type of fully synthetic antibiotics, first synthesized in Japan in 1975, and officially put into operation in 1981 in China. Practice has shown that, PPA Gram-negative bacteria have good bacteriostatic and bactericidal effect, the application of more and more widely, but the clinical findings of more and more adverse reactions, are combined with the cases we have encountered and review the literature, The adverse reactions summarized in the next, for clinical reference.