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Ondansetron(商品名:枢复宁,Zofran)的化学名为1、2、3、9,—四氢—9—甲基—3—〔(2—甲基—1H—眯唑基—1—)甲基〕—4H—咔唑酮,是第一个用于临床的专属性5—HT_3受体拮抗剂,是预防和治疗由化疗药物引起的恶心和呕吐的安全有效药物,该药由英国葛兰素药厂开发,并于1991年上市,我国已批准进口,但价格昂贵,为了减轻癌症患者的痛苦和降低治疗费用,国内齐鲁制药厂与中国医科院药物所共同研制和生产了Ondansetron,现已获得卫生部颁发的新药证书和试生产文号。
The chemical name of Ondansetron (trade name: Zofran) is 1,2,3,9-tetrahydro-9-methyl-3 - [(2-methyl-1H-imidazol-1- Methyl] -4H-carbazolone, the first 5-HT 3 receptor antagonist used clinically, is a safe and effective drug for the prevention and treatment of nausea and vomiting caused by chemotherapeutic drugs, Blue prime pharmaceutical factory development and listing in 1991, China has approved the import, but expensive, in order to reduce the pain of cancer patients and reduce treatment costs, the domestic Qilu Pharmaceutical Factory and the Chinese Academy of Medical Sciences jointly developed and produced Ondansetron, is Has been issued by the Ministry of Health new drug certificate and trial production number.