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目的：探讨正常大小卵巢癌综合征患者的临床特点，诊断标准，治疗方法和预后。方法：回顾性分析１９９４年１月至１９９９年１月在本院治疗及病理复核证实的１８例正常大小卵巢癌综合征，其中卵巢浆液性腺癌１２例，ＥＰＳＰＣ（卵巢外腹膜浆液性乳头状腺癌）３例，卵巢子宫内膜样腺癌１例，原发灶不明的转移性腺癌２例。上述无论何种类型，均施行了最大限度肿瘤细胞减灭术及术后选用ＰＣ方案或ＴＡＸＯＬ＋ＤＤＰ方案或ＩＰ方案或ＥＰ方案等综合化疗。结果：５例卵巢浆液性腺癌，随访至１９９９年３月健在，分别存活４０个月，２３个月，２３个月，１１个月，９个月。另２例ＥＰＳＰＣ随访至１９９９年３月健在，分别存活２０个月，９个月。９例已死亡患者平均生存１４．２个月。２例失访。结论：应重视正常大小卵巢癌综合征鉴别诊断，首选手术治疗，最大限度肿瘤细胞减灭术，术后辅以有效化疗，以获得最佳生存和预后。
Objective: To investigate the clinical features, diagnostic criteria, treatment and prognosis of patients with normal ovarian cancer. Methods: A retrospective analysis of 18 cases of normal ovarian cancer syndrome confirmed by our hospital from January 1994 to January 1999 were retrospectively reviewed. Among them, 12 cases of ovarian serous adenocarcinoma, EPSPC (extraperitoneal ovarian serous papillary thyroid gland Cancer) in 3 cases, ovarian endometrioid adenocarcinoma in 1 case, primary tumor unknown metastatic adenocarcinoma in 2 cases. No matter what type of the above, are implemented the maximum tumor cytoreductive surgery and postoperative choice of PC program or TAXOL + DDP program or IP program or EP regimen combined chemotherapy. Results: Five cases of ovarian serous adenocarcinoma were followed up until March 1999 and survived for 40 months, 23 months, 23 months, 11 months and 9 months respectively. The other two cases of EPSPC were followed up until March 1999 and survived for 20 months and 9 months respectively. Nine patients who died had an average survival of 14.2 months. 2 cases were lost. Conclusion: The differential diagnosis of ovarian cancer syndrome with normal size, the first choice of surgical treatment, the maximal cytoreductive surgery and postoperative chemotherapy supplementation should be emphasized to obtain the best survival and prognosis.