一、第三因子与逃逸现象把大量盐皮质激素(醛固酮)持续给肾功能正常的动物和人,最初数日尿中钠排泄减少,体内钠储留,一定期摄取过剩,钠从尿中排泄,体内钠潴留不增加,从钠储留到肾排钠亢进为逃逸现象,其机制主要为内因性钠利尿激素。 Wardenerd用犬做交叉灌流实验,观察肾小球滤过率(GFR)和醛固酮以外有关钠排泄因素谓第三因子。其后研究结果称内因性洋地黄样物质、钠利尿激素等,认为对容量负荷通过左心房压力感受器,反射传导到中枢,释放出第三因子,分泌部 First, the third factor and the phenomenon of escape A large amount of mineralocorticoid (aldosterone) continued to normal renal function in animals and humans, the first few days to reduce the excretion of sodium in urine, sodium retention in the body, a period of excess intake of sodium excretion from the urine , The body does not increase sodium retention, sodium retention from the kidneys to escape the phenomenon of hyperthyroidism, the mechanism is mainly due to the intrinsic sodium diuretic hormone. Wardenerd dogs with cross-perfusion experiments to observe the glomerular filtration rate (GFR) and aldosterone related to sodium excretion factor that the third factor. Subsequent studies have described endogenous digitalis-like substances, sodium diuretic hormone, etc., that the capacity load through the left atrial baroreceptor, reflex conduction to the central nervous system, the release of the third factor, secretion