原发性高血压患者血浆神经肽Y、神经降压素水平与心功能损害及其预后的相关性(英文)

来源 :中国临床康复 | 被引量 : 0次 | 上传用户:chier00
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
背景:研究证实神经肽Y和神经降压素(neurotensin,NT)具有重要的血管调节作用,与原发性高血压的发生发展有密切关系,而其与靶器官损害及其预后的关系有待进一步研究。目的:探讨原发性高血压病患者血浆神经肽Y及NT水平的变化,以及与高血压性心功能损害的关系。设计:以诊断为依据的横断面研究。地点、对象和方法:选择符合原发性高血压诊断标准的解放军第304医院住院患者80例,28例健康查体者或健康志愿者作为对照。用放射免疫分析法检测血浆神经肽Y,NT浓度,同时检查患者心脏结构和功能。主要观察指标:按原发性高血压病分期、心功能分级、心脏左室后壁和室间隔厚度分类后测定的血浆神经肽Y,NT浓度。结果:原发性高血压Ⅰ,Ⅱ,Ⅲ期3组患者血浆神经肽Y浓度分别为(101±31),(153±41),(198±46)ng/L,差异有显著性意义(P=0.0001);3组患者血浆NT水平分别为(96±32),(78±31),(54±24)ng/L,差异有显著性意义(P=0.0001)。原发性高血压病患者按心功能分级分为1,2,3级3组,神经肽Y浓度分别为(112±34),(159±33),(216±40)ng/L,差异有显著性意义(P=0.0001);3组NT浓度分别为(99±27),(68±30),(48±15)ng/L,差异有显著性意义(P=0.0001),随心功能恶化,神经肽Y水平升高,而NT水平降低。原发性高血压患者伴有室间隔和(或)左室? BACKGROUND: Studies have shown that neuropeptide Y and neurotensin (NT) have important regulatory effects on blood vessels and are closely related to the occurrence and development of essential hypertension. However, the relationship between neuropeptide Y and neurotensin the study. Objective: To investigate the changes of plasma neuropeptide Y and NT levels in patients with essential hypertension and its relationship with impaired cardiac function. Design: A cross-sectional study based on diagnosis. Location, Subjects and Methods: 80 hospitalized patients in the 304th People’s Liberation Army (PLA), 28 healthy volunteers or healthy volunteers were selected as the control group. Radioimmunoassay was used to detect the plasma neuropeptide Y and NT concentrations and to examine the cardiac structure and function of the patients. MAIN OUTCOME MEASURES: Plasma neuropeptide Y and NT concentrations were determined according to the classification of primary hypertension, cardiac function classification, left ventricular posterior wall and ventricular septal thickness. Results: The levels of plasma neuropeptide Y in patients with primary hypertension Ⅰ, Ⅱ and Ⅲ were (101 ± 31), (153 ± 41) and (198 ± 46) ng / L, respectively, with significant difference P = 0.0001). The levels of plasma NT in the three groups were (96 ± 32), (78 ± 31) and (54 ± 24) ng / L, respectively. The difference was statistically significant (P = 0.0001). The patients with essential hypertension were divided into three groups according to their cardiac function classification. Neuropeptide Y concentrations were (112 ± 34), (159 ± 33) and (216 ± 40) ng / L, respectively (P = 0.0001). The NT concentrations of the three groups were (99 ± 27), (68 ± 30) and (48 ± 15) ng / L respectively. There was a significant difference between the two groups (P = 0.0001) Exacerbation, neuropeptide Y levels increased, while NT levels decreased. Essential hypertension with ventricular septum and (or) left ventricle?
其他文献
冀东水泥是国家重点支持的12家大型水泥集团和中国上市公司500强企业之一,作为其下属的区域化管理机构,冀东水泥东北大区是冀东水泥的骨干产业区。都说作为集团或大企业的负
刑法机能应当定位于保护社会和保障人权,刑事法治要担负起这两方面的重任。一方面通过惩罚犯罪保护社会,保护刑事被害人的利益,努力修复遭受破坏的社会关系。另一方面要保障
受贿罪中的利用职务之便与收受财物行为之间并无时间上排列的要求,即使事前无约定亦不该不影响离职后受贿行为的认定。 The absence of a time-series requirement between
抽象危险犯和具体危险犯存在差别,它不需要危险判断,它的存在具有合理性,是社会现实的需要,但抽象危险犯在我国存在立法不够完善的缺陷,有待解决,从而完善我国法律体系。 Th
多项二级预防试验证实,普伐他汀和阿司匹林均可降低心血管疾病的发病危险。普伐他汀主要有延迟抗动脉硬化作用,而阿司匹林具有即时抗血小板效应。为评价两种药物合用能否获
服务群众  1963年12月11日,焦裕禄来到社员张传德家,看到张的爱人抱着一岁的男孩不停地流泪,忙上前询问,得知孩子得了好几种病,在当地看了一个多月不见好转。他赶紧到大队给县医院院长高芳轩打了电话,要他们好好给孩子治疗。随后他又写了一封信,让张传德带上到县医院去。孩子住院期间,焦裕禄曾3次电话询问病情。  艰苦朴素  1964年2月7日,国家给兰考拨来一批救济棉花。救灾办公室的同志看到焦裕禄的棉
“舒张性”心力衰竭 (HF)的概念来源于许多有明显HF症状和体征而左室射血分数正常 (LVEF 0 .4 5 )的患者。由于患者收缩功能指标仍“正常” ,故认为患者HF的症状和体征是由舒
通过互联网访问调查了二十几个省市级图书馆以及港澳台公共图书馆网站,针对目前网站建设中仍存在的问题提出了几个拓展性的建议,具体措施包括开展广泛宣传、提供增值服务、完
问题:5类降压药不同剂量及联合应用的安全性和有效性如何? 方法 数据来源:Medline(1966~2000年,包括2001年的血管紧张素Ⅱ受体拮抗剂的研究)、(Cochrane的维持剂量)降压幅度
“授之以鱼,饱餐一顿;授之以渔,饱餐终生”。在党的群众路线教育实践活动中,四平市安监局转变思想,变执法为服务,把教会企业自身预防事故并杜绝事故作为根本任务。在执法检查