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High-spin states in 145Tb have been populated using the 118Sn (32S, 1p4n) reaction at beam energy of 165 MeV. The level scheme of 145Tb has been established up to Ex ≈7.4 MeV. The level scheme shows characteristics of a spherical or slightly oblate nucleus. Based on the systematic trends of the level structure in the neighboring N = 80 isotones, the level structure in 145Tb below 2 MeV excitation is well explained by coupling an h11/2valence proton to the even-even 144Gd core. Above 2 MeV excitation, most of the yrast levels are interpreted with multi-quasiparticle shell-model configurations.