近日,一项刊登在国际杂志Science上的研究论文中,来自MIT和哈佛大学的研究人员利用两种互补的分析方法首次在人类基因组中鉴别出了对人类细胞系和培养的人类细胞的生存和增殖都非常关键且必要的基因,相关研究或可帮助科学家们寻找多种癌症中的药物靶向性的遗传缺陷。文章中,研究者利用CRISPR基因编辑系统开发出了一种由单链引导的RNAs(sg RNAs)组成的全基因组文库,来筛选并且鉴别细胞维持活 Recently, in a research paper published in the journal Science, researchers from MIT and Harvard University identified for the first time in the human genome, the survival of human cell lines and cultured human cells using two complementary assays Proliferation is a key and necessary genes, research or may help scientists to find a variety of cancer drug-targeted genetic defects. In the article, the researchers used the CRISPR gene editing system to develop a whole-genome library of single-stranded RNAs (sg RNAs) to screen for and identify cell-survival