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目的:探究综合护理配合替莫唑胺化疗治疗中晚期恶性胶质瘤的临床效果。方法:选取2014年4月至2016年10月于我院接受治疗的28例中晚期恶性胶质瘤患者,将其随机分为两组,试验组和对照组分别为14例,对试验组患者行综合护理配合替莫唑胺化疗治疗,对照组则单纯行替莫唑胺化疗,对两组的未进展存活率进行比较,并对末次疗程客观疗效指标CR、PR、SD和PD进行比较。结果:试验组的未进展存活率较之对照组有明显的提高,其差异具有统计学意义(P<0.05)。观察组与对照组比较生存质量评分,其中躯体功能、社会功能、心理健康、痛疼、精力、体力、角色状态良均有明显差异(P<0.05)。结论:综合护理配合替莫唑胺化疗对治疗中晚期恶性胶质瘤有着显著的缓解作用。
Objective: To investigate the clinical effect of comprehensive nursing combined with temozolomide chemotherapy in the treatment of middle-late stage glioblastoma. Methods: From April 2014 to October 2016 in our hospital for treatment of 28 cases of advanced glioblastoma patients were randomly divided into two groups, the experimental group and the control group were 14 cases of patients in the test group Combined with temozolomide chemotherapy, the control group was treated with temozolomide alone. The progression-free survival rate was compared between the two groups. The objective efficacy indexes CR, PR, SD and PD of the last course of treatment were compared. Results: The survival rate of experimental group was significantly higher than that of control group, the difference was statistically significant (P <0.05). The quality of life scores of the observation group and the control group were significantly different (P <0.05), including physical function, social function, mental health, pain, energy, physical strength and character status. Conclusion: The comprehensive nursing combined with temozolomide chemotherapy has a significant effect on the treatment of advanced glioma.