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牛血铜，锌-超氧化物歧化酶（Cu，Zn－SOD）用高碘酸钠活化的β-环糊精（β-Cyclodextrin，β-CD）修饰。对修饰酶静脉注射兔体进行药代动力学研究，结果表明β－CD修饰的SOD在兔体内基本符合二室模型，其特征方程为C＝236e－7.0937t＋60e-0.4473t，修饰SOD的T为0．11±0．04h和1．66±0．48h，体内CLB为53±11．10L／（kg·h），曲线下面积AUC为176．5±35．40U（L·h）。
Bovine serum copper and zinc-superoxide dismutase (Cu, Zn-SOD) were modified with sodium periodate-activated β-cyclodextrin (β-CD). The pharmacokinetics of rabbit with modified enzyme was studied. The results showed that the β-CD modified SOD basically conformed to the two-compartment model with the characteristic equation C = 236e-7.0937t + 60e-0.4473t. The modified T 0.11 ± 0.04 h and 1.66 ± 0.48 h respectively. The in vivo CLB was 53 ± 11.10 L / (kg · h). The area under the curve AUC was 176.5 ± 35.40 U (L · h).