作者将54例经质子泵抑制剂治疗仍发生夜间烧心症状的NERD患者,分别于睡前加服奥美拉唑、法莫替丁和法莫替丁加阿普唑仑,7d后发现奥美拉唑组夜间pH<4的时间百分比和NAB的发生率均高于其他2组;法莫替丁组平均夜间烧心症状的VAS总积分低于奥美拉唑组而高于联用阿普唑仑组。表明阿普唑仑能帮助法莫替丁减少NERD夜间烧心症状。 In this study, 54 patients with NERD who were treated with proton pump inhibitors for nighttime heartburn symptoms were treated with omeprazole, famotidine and famotidine plus alprazolam at bedtime. After 7 days, The percentage of time of pH <4 at night and the incidence of NAB were higher in the group of lazole than those in the other two groups. The average score of VAS in the group of famotidine at night was lower than that in the group of omeprazole, Lun group. That alprazolam can help famotidine reduce NERD heartburn symptoms at night.