自1925年维也纳的外科医生Mandl证实了甲状旁腺腺瘤和骨损害(纤维囊性骨炎)之间的关系,明确了原发性甲状旁腺机能亢进症(甲旁亢)的病因,至今已有80年。但从20世纪60~70年代血清钙离子测定用于临床筛查以来,甲旁亢的检出率才明显增加。相比其他内分泌腺疾病,甲旁亢还是较少见,大 Mandl, a 1952 surgeon in Vienna, confirmed the relationship between parathyroid adenoma and bone damage (fibrocystic osteitis) and identified the etiology of primary hyperparathyroidism (hyperparathyroidism) to date 80 years. However, since the seventy to seventies of the 20th century, serum calcium determination for clinical screening, the detection rate of hyperparathyroidism was significantly increased. Compared with other endocrine diseases, hyperparathyroidism is still rare, large