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目的:检测雌激素受体(ER)、孕激素受体(PR)阴性乳腺癌组织中连环蛋白P120(P120ctn)的表达,分析其与临床病理因素的关系。方法:采用免疫组织化学染色的方法对比分析了52例ER、PR阴性乳腺癌组织和23例癌旁正常乳腺组织及21例乳腺纤维腺瘤组织中P120ctn的表达。结果:52例ER、PR阴性乳腺癌组织中有32例P120ctn(61.53%)膜表达弱阳性或阴性表达,29例(52.76%)胞质表达阳性,总异常表达35例(67.30%)。21例乳腺纤维腺瘤组织中膜表达弱阳性6例(28.57%),胞质无表达。23例癌旁正常乳腺组织仅有2例为膜表达弱阳性(8.69%),其余均为胞膜正常表达。三者比较差异有显著性。结论:P120ctn在ER、PR阴性乳腺癌的异常表达明显,可作为评估预后的一项有价值指标。
OBJECTIVE: To detect the expression of P120ctn in estrogen receptor (ER) and progesterone receptor (PR) -negative breast cancer tissues and to analyze its relationship with clinicopathological factors. Methods: The expressions of P120ctn in 52 cases of ER, PR negative breast cancer tissues, 23 cases of adjacent normal breast tissues and 21 cases of breast fibroadenomas were analyzed by immunohistochemical staining. Results: The expression of P120ctn (61.53%) in the 52 cases of ER and PR negative breast cancer tissues was weakly positive or negative, while in 29 cases (52.76%) the positive expression of cytoplasm was found in 35 cases (67.30%). In 21 cases of breast fibroadenoma, the expression of membrane was weakly positive in 6 cases (28.57%), the cytoplasm was not expressed. Only 23 cases of adjacent normal breast tissue showed weak positive expression of membrane (8.69%), while the rest were normal expression of the membrane. Three differences were significant. Conclusion: The abnormal expression of P120ctn in ER and PR negative breast cancer can be used as a valuable index to evaluate the prognosis.