葡萄牙人于１６世纪中期入居澳门后，除大力发展里斯本至澳门、澳门至日本的航运与贸易外，还开辟了新的澳门──马尼拉航线与贸易。菲律宾的马尼拉成为澳门葡人同东南亚地区开展海上贸易的重要地区，其重要性仅次于对日贸易。（一）在葡人入居澳门之前，中国东南沿海地区（主 After the Portuguese settled in Macao in the mid-16th century, they not only made great efforts to develop the shipping and trade from Lisbon to Macao and Macao to Japan, but also opened up a new Macao-Manila route and trade. Manila in the Philippines has become an important area where Macao’s Portuguese people conduct maritime trade with Southeast Asia, second only to trade with Japan. (1) Prior to the Portuguese occupation in Macao, the coastal areas in southeastern China (Lord