目的　探讨利用多普勒组织成像 (Dopplertissueimaging ,DTI)评价链尿佐诱导的兔糖尿病 (diabetesmellitus ,DM )模型早期糖尿病心肌病左室舒张功能障碍的价值 ,以及糖尿病心肌病左室舒张功能障碍的演变规律及发生机制。方法　应用DTI技术测定DM兔左室近二尖瓣的后间隔和侧壁处的DTI各指标 :舒张早期速度Ea ,舒张晚期速度Aa以及Ea Aa值 ,并同 10只正常组兔对照。结果　左室舒张功能障碍出现在模型成功复制后 4周 ,随病情发展而加重 ,病理检查排除了冠状动脉疾病。结论　多普勒组织成像能够发现早期的糖尿病心肌病左室舒张功能障碍。 Objective To investigate the value of Doppler tissue imaging (DTI) in the assessment of left ventricular diastolic dysfunction in diabetes mellitus (DM) induced by streptozotocin in diabetic nephropathy and the changes of left ventricular diastolic dysfunction in diabetic cardiomyopathy Laws and mechanisms. Methods DTI technique was used to measure the indexes of DTI at the posterior septum and the lateral wall of the proximal mitral valve in DM rabbits: early diastolic velocity Ea, late diastolic velocity Aa and Ea Aa, and compared with 10 normal rabbits. Results Left ventricular diastolic dysfunction occurred 4 weeks after successful replication of the model, with the progression of the disease aggravated, and pathological examination excluded coronary artery disease. Conclusion Doppler tissue imaging can detect left ventricular diastolic dysfunction in early diabetic cardiomyopathy.