目的　研究新型放射增敏剂丁胱亚磺酰亚胺（ｂｕｔｈｉｏｎｅ ｓｕｌｆｏｘｉｍ ｉｎ， Ｂ Ｓ Ｏ）对 Ａｃｃ２ 细胞的放射增敏效应。方法　采用克隆形成法，首先观察了 Ｂ Ｓ Ｏ 在乏氧状态和有氧状态下对 Ａｃｃ２ 细胞的药物毒性，然后研究了 Ｂ Ｓ Ｏ 在乏氧和有氧状态下对 Ａｃｃ２ 细胞的放射增敏效应。结果　 Ｂ Ｓ Ｏ 在乏氧状态和有氧状态时，其半数抑制剂量分别为８０μｍ ｏｌ／ Ｌ、１２０μｍ ｏｌ／ Ｌ。当 Ｂ Ｓ Ｏ 在 Ｉ Ｄ２０、 Ｉ Ｄ１０ 的药物剂量时，在乏氧状态下，其 Ｓ Ｅ Ｒ 值分别为１５２１ 和１２６３，在有氧状态下其 Ｓ Ｅ Ｒ 值分别为１２９６ 和１１５３。结论　 Ｂ Ｓ Ｏ 对 Ａｃｃ２ 细胞有放射增敏作用， Ｂ Ｓ Ｏ 在乏氧状态下的增敏效应比有氧状态下的放射增敏效应强。 Objective To study the radiosensitization effect of novel radiosensitizer buthione sulfoximin (B S O) on Acc2 cells. Methods The clonogenic method was used to observe the drug toxicity of B S O to Acc2 cells under hypoxic condition and aerobic condition. Then the effect of B S O on Acc2 cells under hypoxia and aerobic condition Radiosensitization effect. Results The results showed that the half-maximal inhibitory concentrations of B S O were 80 μmol / L and 120 μmol / L, respectively, under hypoxic condition and aerobic condition. The S E R values ​​of B S O were 1521 and 1263 under hypoxia when the dose of B S O was at I D20 and I D10, respectively, and their S E R values ​​under aerobic condition were 1  1 respectively. 296 and 1  153. Conclusion B S O had a radiosensitizing effect on Acc2 cells. The sensitizing effect of B S O in hypoxic condition was stronger than that in aerobic condition.