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肺损伤(injury of lung)按照时效性可分为急性肺损伤和慢性肺损伤。急性肺损伤(acute lung injury,ALI)是各种复杂因素导致的肺泡上皮细胞及毛细血管内皮细胞损伤,造成弥漫性肺间质及肺泡水肿,严重阶段(氧合指数<200)也称为急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)。慢性肺损伤为慢性支气管炎、肺间质纤维化形成或肺癌等慢性损伤。分泌型磷脂酶A2(sPLA2)是花生四烯酸、溶血磷脂等炎性介质的限速酶,它促进一系列炎性介质和细胞因子释放和激
Injury lung injury can be divided into acute lung injury and chronic lung injury according to the timeliness. Acute lung injury (ALI) is an injury of alveolar epithelial cells and capillary endothelial cells caused by various complicated factors, causing diffuse pulmonary interstitial and alveolar edema. Serious stages (oxygen index <200) are also called acute Respiratory distress syndrome (ARDS). Chronic lung injury is chronic bronchitis, pulmonary interstitial fibrosis or lung cancer and other chronic injury. Secreted phospholipase A2 (sPLA2) is a rate-limiting enzyme in arachidonic acid, lysophospholipid and other inflammatory mediators, it promotes a series of inflammatory mediators and cytokines release and stimulation