肝纤维化为诸多慢性肝病发展至肝硬化过程中所共有的组织学变化,是影响慢性肝病预后的重要环节[1]。十多年来,肝纤维化的基础研究在分子生物学和细胞信号传递领域不断取得飞速的发展,细胞因子与肝纤维化的关系成为当前研究的重点内容。业已证明,多种细胞因子参与了肝纤维化的启 Hepatic fibrosis is a common histological change in the development of many chronic liver diseases to cirrhosis and is an important part of the prognosis of chronic liver disease [1]. For more than a decade, the basic research of liver fibrosis has made rapid progress in the field of molecular biology and cell signaling. The relationship between cytokines and hepatic fibrosis has become the focus of current research. It has been demonstrated that many cytokines are involved in the development of hepatic fibrosis