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目的：观察替吉奥与吉西他滨同步放化疗治疗局部晚期胰腺癌的临床疗效。方法随机选取2013年1月至2014年6月在我院治疗局部晚期胰腺癌的34例患者进行本次的研究，将其随机分为对照组（n=17）和治疗组（n=17），对照组采取5氟尿嘧啶联合吉西他滨同步放化疗，观察组采取替吉奥联合吉西他滨同步放化疗，观察比较两组患者的临床治疗情况。结果观察组患者的近期疗效优于对照组患者，差异有统计学意义，X2=0.010，P＜0.05，两组患者的不良反应发生率差异无统计学意义，X2=0.287，P＞0.05。结论替吉奥与吉西他滨同步放化疗治疗局部晚期胰腺癌的临床疗效较为明显，值得进一步研究。“,”Objective To observe for gonow and gemcitabine chemoradiation clinical curative effect for the treatment of locally advanced pancreatic cancer. Methods Randomly selected from January 2013 to June 2014 in our hospital to treat 34 cases of locally advanced pancreatic cancer patients in the study, will be randomly divided into control group (n=17) and treatment group (n=17), the control group take 5 fluorouracil in combination with gemcitabine chemoradiation, observation group takes for gonow combination gemcitabine chemoradiation, observe the clinical treatment of two groups were compared. Results The observation group of patients with a recent curative effect is better than the control group patients, difference was statistically significant, X2=0.010, P0.05). Conclusion For gonow and gemcitabine chemoradiation in the treatment of locally advanced pancreatic cancer clinical curative effect more apparent, deserves further research.