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目的观察伊贝沙坦治疗老年高血压病的临床疗效。方法 4 0例老年高血压病患者服用伊贝沙坦 15 0mg ,1次 /d ,根据疗效调整用量为 75～ 30 0mg ,1次 /d ,疗程 4周。结果降压疗效 :显效 14例 (35 .0 % ) ,有效 2 1例 (5 2 .5 % ) ,无效 5例 (12 .5 % ) ,总有效率 87.5 % ;心电图有心肌缺血表现 36例 ,心电图疗效 :显效 8例 (2 2 .2 % ) ,有效 13例 (36 .1% ) ,无效 15例 (4 1.7% ) ,总有效率 5 8.3%。治疗 4周后与治疗前比较 ,坐位血压明显下降 [治疗前 (171.5± 13.6 ) /(96 .2± 8.2 )mmHg,治疗后 (135 .8± 7.6 ) / (75 .9± 6 .7)mmHg ,P <0 .0 1],心率无明显变化 (P >0 .0 5 ) ,检测 2 4小时动态血压计算降压谷峰比值率 >6 5 %。临床症状明显改善 ,不良反应轻微 ,均能耐受治疗 ,血脂、血糖和肝肾功能无显著变化 (P >0 .0 5 )。结论伊贝沙坦治疗老年高血压病安全有效。
Objective To observe the clinical efficacy of irbesartan in the treatment of elderly patients with essential hypertension. Methods 40 elderly hypertensive patients were treated with irbesartan 150 mg once daily for 75 to 300 mg once daily for 4 weeks. The results of antihypertensive effect: effective in 14 cases (35.0%), effective 21 cases (52.5%), 5 cases (12.5%), the total effective rate was 87.5%; ECG showed myocardial ischemia 36 Efficacy of ECG: 8 cases (22.2%) were markedly effective, 13 (36.1%) effective and 15 (4 1.7%) ineffective with a total effective rate of 8.33%. After 4 weeks of treatment, there was a significant decrease in sitting blood pressure [before treatment (171.5 ± 13.6) / (96.2 ± 8.2) mmHg and after treatment (135.8 ± 7.6) / (75.9 ± 6.7) mmHg, P <0.01], no significant changes in heart rate (P> 0.05). The ratio of peak to peak blood pressure was calculated to be> 65% at 24 hours. Clinical symptoms were significantly improved with mild adverse reactions. All patients were able to tolerate the treatment without significant changes in blood lipid, blood glucose, liver and kidney function (P> 0.05). Conclusion Irbesartan in the treatment of elderly patients with hypertension is safe and effective.