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RU486是一种有效的孕酮拮抗剂,它抑制孕酮对子宫的作用,目前已将其作为中止早孕的堕胎药试用于临床。本文就RU486对离体胎盘细胞的作用进行了研究。方法:从无妊娠合并症行剖腹产的妇女取足月胎盘。迅速进行离体培养。以放免法测定hCG、hPL和孕酮。结果:人足月胎盘细胞滋养层在48小时培养中分化为合胞体滋养层,并使hCG、hPL和孕酮量增加。细胞培养后的24小时孕酮拮抗剂浓度增至10nmol～10μmol/l,评价RU486对胎盘激素分泌的
RU486 is an effective progesterone antagonist that inhibits the effect of progesterone on the uterus and has now been tested as an abortifacient for aborting early pregnancy. In this paper, RU486 on the role of isolated placental cells were studied. METHODS: Full-term placentas were obtained from women who did not have a pregnancy-induced complication of caesarean section. Rapid in vitro culture. The hCG, hPL and progesterone were determined by radioimmunoassay. RESULTS: Human full-term placental trophoblasts differentiated into syncytiotrophoblast during 48 hours of culture and increased hCG, hPL, and progesterone levels. 24 hours after cell culture, the concentration of progesterone antagonist increased to 10nmol ~ 10μmol / l, RU486 evaluation of placental hormone secretion