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目的探讨P16蛋白与胃癌生物学行为的关系。方法采用免疫组化SP法检测33例胃癌、17例癌旁和13例正常胃粘膜中P16蛋白的表达。结果胃癌P16蛋白阳性表达率明显高于正常胃粘膜（P＜0．05）。癌旁与正常胃粘膜、胃癌阳性表达之间无显著性差异（P＞0．05）。伴淋巴结转移胃癌阳性细胞密度高于未转移者（P＜0．05）。P16蛋白表达与胃癌的其它生物学行为无统计学相关。结论P16基因异常有促进胃癌转移的效应，可作为胃癌预后的一个参考指标。
Objective To investigate the relationship between P16 protein and the biological behavior of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of P16 protein in 33 cases of gastric cancer, 17 cases of adjacent cancer and 13 cases of normal gastric mucosa. Results The positive expression rate of P16 protein in gastric cancer was significantly higher than that in normal gastric mucosa (P<0.05). There was no significant difference between paracancerous and normal gastric mucosa and gastric cancer (P>0.05). The positive cell density of gastric cancer with lymph node metastasis was higher than that without metastasis (P<0.05). There was no statistical correlation between the expression of P16 protein and other biological behaviors of gastric cancer. Conclusion The abnormality of P16 gene has the effect of promoting the metastasis of gastric cancer, and it can be used as a reference index for the prognosis of gastric cancer.