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目的了解本院儿童真菌感染状况、菌种分布及耐药情况。方法回顾分析2011年-2014年临床确诊为深部真菌感染的280例住院患儿的临床资料,探讨其真菌感染的临床特点、病原学分布及其药物敏感性等。结果儿童真菌感染标本主要来源于咽拭子标本,且白假丝酵母菌的分离率最高(60.00%),其次为光滑假丝酵母菌、热带假丝酵母菌和近平滑假丝酵母菌。药敏结果显示,耐药率较低的药物是两性霉素B(1.59%)和5-氟胞嘧啶(3.19%),耐药率较高的药物是氟康唑(12.35%)和伊曲康唑(15.94%)。结论儿童深部真菌感染多为假丝酵母菌,且以白假丝酵母菌的检出率最高;Am B、5-FC均有较高的抗真菌活性。应加强对临床真菌感染与耐药性监测,指导临床合理使用抗真菌药物。
Objective To understand the status of fungal infection in children, the distribution of bacteria and drug resistance. Methods The clinical data of 280 hospitalized children with clinically diagnosed deep fungal infection from 2011 to 2014 were analyzed retrospectively to investigate the clinical features, etiological distribution and drug sensitivity of their fungal infections. Results The specimens of fungal infections in children mainly came from throat swab specimens. Candida albicans isolates were the highest (60.00%), followed by Candida glabrata, Candida tropicalis and Candida parapsilosis. Drug susceptibility results showed that the drug with lower drug resistance rate was amphotericin B (1.59%) and 5-fluorocytosine (3.19%), and the drug with higher drug resistance rate was fluconazole (12.35%) and iqtra Conazole (15.94%). Conclusion Most children with fungal infection of Candida albicans, Candida albicans and the highest detection rate; Am B, 5-FC have a higher antifungal activity. Should strengthen the clinical fungal infection and drug resistance monitoring, clinical rational use of antifungal agents.