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目的 观察 6只新西兰白兔灌服罗红霉素前后对氨茶碱稳态血药浓度及药代动力学的影响。方法 实验分二期 :Ⅰ期为d 1～ 4单独灌服氨茶碱至稳态 ;Ⅱ期为d 5～ 10合用罗红霉素与氨茶碱 ,血药浓度采用HPLC法测定。结果 各期测得氨茶碱药代动力学参数 ,与Ⅰ期比较 ,Ⅱ期的AUC、CL/Fs、Ka、Ke、T1/ 2 (ka) 、Tmax差异有显著性 (P <0 0 5 ,P <0 0 1) ,而Cmax、V/Fc、T1/ 2 (ke) 在两期间差异均无显著性(P >0 0 5 )。结论 长期合用罗红霉素和氨茶碱 ,罗红霉素能延缓氨茶碱在兔体内稳态时的吸收和消除 ,提示合并用药时应对氨茶碱进行临床给药监测。
Objective To observe the effects of roxithromycin on steady-state plasma concentration and pharmacokinetics of aminophylline in six New Zealand white rabbits. Methods The experiment was divided into two phases: in the first phase, aminophylline was dosed orally to the steady state with d 1 ~ 4; in the second phase, roxithromycin and aminophylline were d 5 ~ 10, and the plasma concentration was determined by HPLC. Results The pharmacokinetic parameters of aminophylline were determined in each phase. There was a significant difference in the AUC, CL / Fs, Ka, Ke, T1 / 2 (ka) , P <0.01). There was no significant difference in Cmax, V / Fc and T1 / 2 (ke) between the two periods (P> 0.05). Conclusion Long-term use of roxithromycin, aminophylline, and roxithromycin can delay the absorption and elimination of aminophylline in the homeostasis of rabbits, suggesting that aminophylline should be monitored for clinical administration when combined with drugs.