According to the concept of critical plane, a life prediction approach for random multiaxial fatigue is presented. First, the critical plane under the multiaxial random loading is determined based on the concept of the weight-averaged maximum shear strain direction. Then the shear and normal strain histories on the determined critical plane are calculated and taken as the subject of multiaxial load simplifying and multiaxial cycle counting. Furthermore, a multiaxial fatigue life prediction model including the parameters resulted from multiaxial cycle counting is presented and applied to calculating the fatigue damage generated from each cycle. Finally, the cumulative damage is added up using Miner’s linear rule, and the fatigue prediction life is given. The experiments under multiaxial loading blocks are used for the verification of the proposed method. The prediction has a good correction with the experimental results. According to the concept of critical plane, a life prediction approach for random multiaxial fatigue is presented. First, the critical plane under the multiaxial random loading is determined based on the concept of the weight-averaged maximum shear strain direction. Then the shear and normal strain histories on the determined critical plane are calculated and taken as the subject of multiaxial load simplifying and multiaxial cycle counting. Also, a multiaxial fatigue life prediction model including the parameters resulted from multiaxial cycle counting is presented and applied to calculating the fatigue damage generated from each cycle. Finally, the cumulative damage is added up using Miner’s linear rule, and the fatigue prediction life is given. The experiments under multiaxial loading blocks are used for the verification of the proposed method. .