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目的观察子宫内膜异位症假孕疗法与假绝经疗法的临床疗效。方法选取医院收治的子宫内膜异位症患者62例为研究对象,随机分为A组和B组,每组31例。均在月经周期第1天给药,A组采用米非司酮,B组采用达那唑,2组均随诊5个月,观察2组治疗后症状的改变、药物不良反应等情况。结果 A、B 2组痛经的改善比例分别为80.65%、83.87%;性交痛的改善比例分别为77.42%、83.87%;非经期下腹痛的改善比例分别为74.19%、77.42%;子宫活动受限的改善比例分别为83.87%、80.65%,差异均无统计学意义(P>0.05)。根据药物不良反应的调查,B组的不良反应大于A组。B组的性欲下降、潮热、不规则阴道出血、痤疮、阴道干燥、低雌激素症状多于A组,差异有统计学意义(P<0.01)。结论使用米非司酮的假孕疗法和使用达那唑的假绝经疗法相比有相似的临床症状、体征的改善,但前者不良反应较少,值得临床推广应用。
Objective To observe the clinical efficacy of pseudopregnancy and pseudo-menopausal therapy for endometriosis. Methods Totally 62 patients with endometriosis admitted to hospital were selected as study objects and randomly divided into A group and B group, with 31 cases in each group. Both were administered on the first day of the menstrual cycle, mifepristone in group A, danazol in group B, and the two groups were followed up for 5 months to observe the changes of symptoms and adverse drug reactions in the two groups. Results The improvement rates of dysmenorrhea in group A and group B were 80.65% and 83.87% respectively. The improvement rates of pain in sexual intercourse were 77.42% and 83.87% respectively. The improvement rates of non-menstrual and lower abdominal pain were 74.19% and 77.42% The improvement rates were 83.87% and 80.65%, respectively, with no significant difference (P> 0.05). According to the survey of adverse drug reactions, adverse reactions in group B than in group A. B group decreased libido, hot flashes, irregular vaginal bleeding, acne, vaginal dryness, low estrogen symptoms more than the A group, the difference was statistically significant (P <0.01). Conclusion The mifepristone-based pseudopregnancy has similar clinical symptoms and signs compared with the pseudo-menopausal therapy with danazol, but the former has fewer adverse reactions and is worthy of clinical application.