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目的探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)妇女采用不同治疗方案后行供精人工授精(artificial insemination by donor,AID)助孕的临床治疗效果。方法回顾性分析广东省计划生育专科医院61例妇女自然周期或是不同方案促排卵后行AID助孕122个周期,比较不同方案的临床妊娠率的差异。结果周期妊娠率20.83%,累积妊娠率40.98%,不同方案比较,妊娠率差异有统计学意义(P<0.05)。以克罗米芬(clomifene citrate,CC)/人绝经期促性腺激素(human menopausal gonadotropin,HMG)/人绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)促排卵的妊娠率最高,卵泡刺激素(follicle stimulating hormone,FSH)/HCG组妊娠率与他莫昔芬(tamoxifen,TMX)/HMG/HCG组及CC/HMG/HCG组比较,差异有统计学意义(P<0.05)。结论 PCOS妇女调整周期自然排卵可以获得较高的妊娠率,CC/TMX与促性腺激素(gonadotropin,Gn)结合可以增加排卵率和临床妊娠率,减少Gn的应用时间,减少卵巢过度刺激综合征(Ovarian hyperstimulation syndrome,OHSS)的发生。
Objective To investigate the clinical effects of artificial insemination by donor (AID) in pregnant women with polycystic ovary syndrome (PCOS) after different treatment regimens. Methods A retrospective analysis of 61 cases of family planning in Guangdong Province, the natural cycle of women or women with different programs to promote ovulation AID 122 weeks of pregnancy, the difference in clinical pregnancy rates compared. Results The cycle pregnancy rate was 20.83% and the cumulative pregnancy rate was 40.98%. There was significant difference in pregnancy rates between different schemes (P <0.05). Pregnancy with clomifene citrate (CC) / human menopausal gonadotropin (HMG) / human chorionic gonadotrophin (HCG) had the highest pregnancy rate, follicle stimulating (P <0.05). There was significant difference in the pregnancy rate between the FSH / HCG group and the tamoxifen (TMX) / HMG / HCG group and the CC / HMG / HCG group. Conclusion PCOS women can achieve a higher pregnancy rate during spontaneous ovulation cycles. The combination of CC / TMX and gonadotropin (Gn) can increase the ovulation rate and clinical pregnancy rate, reduce the application time of Gn, and reduce the ovarian hyperstimulation syndrome Ovarian hyperstimulation syndrome, OHSS).