慢性高血压是孕期常见临床问题,由于越来越多的孕妇有肥胖与产龄高的问题,其发病率正逐年上升。因此,在怀孕期间,甚至是胚胎器官形成的前3月(孕早期)服用抗高血压药物已经越来越常见。在孕早期服用抗高血压类药物,包括β受体阻滞剂、利尿剂和血管紧张素转换酶抑制剂,已证实与先天畸形相关[1-5]。但是最近一些研究表明,有可能是潜在慢性高血压引起先天畸形而不是药物的影响[1,3,6],因为研究发现, Chronic hypertension is a common clinical problem during pregnancy. As more and more pregnant women have obesity and high age-related problems, their incidence is increasing year by year. As a result, antihypertensive medications are becoming more common during the first trimester of pregnancy, even in the first trimester of pregnancy, during pregnancy. Antihypertensives, including beta blockers, diuretics and angiotensin-converting enzyme inhibitors, have been shown to be associated with congenital malformations during early pregnancy [1-5]. However, some recent studies have shown that it is possible that the underlying chronic hypertension causes congenital malformation rather than drug effects [1, 3, 6]