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建立了水产品中氯丙嗪、乙酰丙嗪、丙酰丙嗪、异丙嗪、甲苯噻嗪等5种吩噻嗪类药物多残留的液质联用确证方法。用碱性乙睛萃取样品中的5种吩噻嗪类药物,然后用HLB固相萃取柱净化,以YMC-PackProC18色谱柱为分离柱,在正离子模式下以电喷雾电离串联质谱仪进行测定。在1.0、2.0、4.0ng/g3个质量浓度水平进行验证试验,方法的线性范围为0.5～5.0ng/g,总体平均回收率为75.7%～87.7%,相对标准偏差为9.0%～15.2%。该方法简便、快速、准确,各项技术指标满足国内外法规的要求,可用于水产品中吩噻嗪类药物残留的确证检测。
The establishment of aquatic products in chlorpromazine, acepromazine, propoxuridine, promethazine, xylazine and other five kinds of phenothiazines multi-residue LC / MS confirmation method. The five phenothiazines in the sample were extracted with basic acetonitrile and then purified with an HLB SPE cartridge using a YMC-PackProC18 column as a separation column in an electrospray ionization tandem mass spectrometer in positive ion mode . The calibration curves were validated at 1.0, 2.0, and 4.0ng / g. The linear range of the method was 0.5 ~ 5.0ng / g, the average recovery was 75.7% ~ 87.7% and the relative standard deviation was 9.0% ~ 15.2%. The method is simple, rapid and accurate, and the technical indicators meet the requirements of domestic and foreign laws and regulations. It can be used to confirm the detection of phenothiazine residues in aquatic products.