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弥漫性血管内凝血(DIC)是许多危重疾病的重要合并症,近年临床已证实不少重症病毒性感染伴有 DIC 而引起死亡。虽然实验医学已观察到大鼠静注流感病毒后,肺中可见广泛微血栓,但尚未见符合临床 DIC 实验室诊断标准、重复性好的病毒所致 DIC 动物模型的报道。基于病毒可与细菌内毒素一样,造成家兔皮肤局部施瓦茨蔓(Shwartz
Diffuse intravascular coagulation (DIC) is an important complication of many critically ill diseases. In recent years, many severe viral infections have been clinically proven to cause death with DIC. Although laboratory medicine has observed widespread micro-thrombi in the lungs after intravenous injection of influenza virus in rats, no animal model of DIC due to reproducible viruses has yet been reported in line with clinical DIC laboratory diagnostic criteria. Based on the fact that viruses can end up with bacterial endotoxins, causing local skin shrews in rabbits (Shwartz