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对小鼠肺腺癌细胞系（ＬＡ－７９５）高、低转移亚系（ＬＡ－７９５－Ｃ＿６和ＬＡ－７９５－Ｃ＿７）体外培养第２０及３０代细胞染色体Ｇ显带核型进行比较，结果高转移亚系细胞染色体众数较低转移亚系细胞具有不稳定性的特点，表明转移潜能的差异和遗传物质的稳定程度密切相关．高、低转移亚系出现相同及不同的标志染色体和异常染色体，其中，高转移亚系出现标志染色体８种及ｄｅｌ（８）ｑ￣（ｔｅｒ），ｄｅｌ（１２）ｑ￣（ｔｅｒ），１１Ｐ￣＋，１３Ｐ￣＋，ｔｒｉ（２Ｍ４），ｄｉｃ（２Ｍ５），Ｍ６：７ｑ￣＋？；而低转移潜能亚系出现标志染色体１２种及ｄｅｌ（８）ｑ￣（ｔｅｒ），ｄｅｌ（１２）ｑ￣（ｔｅｒ），ｒ（１５），ｄｉｃ（Ｍ６；２Ｍ７），Ｍ８：７ｑ￣＿？ｔ（２：２），ｔ（２：１５），ｔ（１５：Ｍ１０），ｔ（１５：Ｍ１１），ｔ（５：Ｍ１２）．表明来源于同一母系而转移潜能不同的亚系染色体核型具有本质上的差异，转移潜能与其密切相关．另外，分析低转移亚系出现ｔ（２：２）；ｔ（Ｃ２：１５）ｔ（１５：Ｍ１０）；ｔ（１５：Ｍ１１）； ｔ（５：Ｍ１２）；ｒ（１５）等现象，推测高、低转移潜能亚系细胞可能存在本身Ｈ－２系统及ＣＤ４４抗元表达的差异，这很可能?
Comparison of chromosome G banding karyotypes in the 20th and 30th passages of high and low metastatic subclones (LA-795-C_6 and LA-795-C_7) of mouse lung adenocarcinoma cell line (LA-795) in vitro. The low metastatic subpopulations of chromosomes with high metastatic sublineage cells are characterized by instability, indicating that the difference in metastatic potential is closely related to the stability of genetic material. The same and different marker chromosomes and abnormal chromosomes appear in the high and low metastatic sublines. Among them, 8 markers and del(8)q(ter),del(12)q(ter),11P appear in the high metastasis subline. ̄+,13P ̄+,tri(2M4),dic(2M5),M6:7q ̄+? ; And low metastatic potential sub-systems appear 12 kinds of marker chromosomes and del (8) q ̄ (ter), del (12) q ̄ (ter), r (15), dic (M6; 2M7), M8: 7q ̄ _ ? t(2:2),t(2:15),t(15:M10),t(15:M11),t(5:M12). It was shown that the chromosome karyotypes of sublineages with different metastatic potentials originated from the same maternal line were essentially different and their metastasis potential was closely related. In addition, the analysis of t(2:2); t(C2:15)t(15:M10); t(15:M11); t(5:M12); r(15), etc. The high and low metastatic potential subline cells may have their own H-2 system and CD44 anti-element expression differences, which is likely?