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目的评估胆道支架联合125I粒子条置入治疗恶性阻塞性黄疸的临床疗效。方法回顾性分析26例胆道支架置入同时在支架与胆管壁之间置入自制125I粒子条治疗恶性阻塞性黄疸病例资料。结果支架通畅时间为(12.1±3.0)个月,95%CI为10.9~13.3;患者生存期为(13.0±2.8)个月,95%CI为11.8~14.1。阻塞性黄疸症状逐渐缓解,总胆红素(TBIL)于直接胆红素(DBIL)与术后2周、1个月均明显下降,肿瘤指标癌胚抗原(CEA)、糖类抗原(CA199)有不同程度下降,与术前对比差异有统计学意义(P<0.01)。结论胆道支架联合125I粒子条置入治疗恶性阻塞性黄疸疗效显著,既能解除胆道梗阻又能抑制肿瘤生长。
Objective To evaluate the clinical efficacy of biliary stent combined with 125I particle implantation in the treatment of malignant obstructive jaundice. Methods The data of 26 patients with malignant obstructive jaundice treated with implantation of 125I particles between stent and bile duct wall were retrospectively analyzed. Results The duration of patency was (12.1 ± 3.0) months and the 95% CI was 10.9-13.3. The patients’ survival was (13.0 ± 2.8) months and the 95% CI was 11.8-14.1. The symptoms of obstructive jaundice were gradually relieved. The total bilirubin (TBIL) was significantly decreased in both DBIL and 2 weeks and 1 month after operation. The tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA199) There was a significant difference between the two groups (P <0.01). Conclusion Biliary stents combined with 125I particles in the treatment of malignant obstructive jaundice have a significant effect, both to relieve biliary obstruction and inhibit tumor growth.