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Objective: To observe the effect of Yishou Tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and atherosclerosis.Methods: Thirty two rabbits were randomly divided into four groups, Group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day;for Group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C, hyperlipid forage was given and for Group D, only ordinary forage was given. Biochemical parameters were measured and pathomorphological examinations were carried out 6 weeks later.Results: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC), triglyceride(TG), atherosclerotic index(AI), apoprotein(ApoB), lipoprotein [Lp(a)], oxygen low density lipoprotein cholesterol(ox LDL), hydroxyproline(HYP), plasma Ca 2+ , thromboxane B 2(TXB 2), and increased the levels of serum high density lipoprotein cholesterol(HDL C), apoprotein A 1(Apo A 1), ApoA 1 /ApoB, plasma 6 keto PGF 1α ( P <0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen.Conclusion: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.
Objective: To observe the effect of Yishou Tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and atherosclerosis.Methods: Thirty two rabbits were randomly divided into four groups, Group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C, Hyperlipid forage was given and for Group D, only ordinary forage was given. Biochemical parameters were measured and pathomorphological examinations were carried out 6 weeks later.Results: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC), triglyceride(TG ), atherosclerotic index (AI), apoprotein (ApoB), lipoprotein [Lp(a)], oxygen low density lipoprotein cholesterol (ox LDL), hydroxyproline (HYP), plasma Ca 2+, thromboxane B 2 (TXB 2), and Increased the levels of serum hi Gh density lipoprotein cholesterol (HDL C), apoprotein A 1 (Apo A 1), ApoA 1 /ApoB, plasma 6 keto PGF 1α ( P <0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and Arterial intima thickness reduced reduced, smooth muscle cell hyperplasia and elastic fibers were not seen.Conclusion: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.