在全球范围内每年有超过1200万的早产儿诞生。早产儿突然从妈妈温暖的子宫内转入到新生儿重症监护病房(neonatal intensive care unit,NICU)接受必要的抢救和治疗,执行很多侵入性护理操作,从而产生疼痛的经历。有研究表明~([1]),胎龄不足29周的早产儿在NICU停留3个月期间需经历300次或更多的痛苦操作,如足跟采血、动静脉穿刺、各类注射、气管插管、吸痰、PICC、眼底检查等,有报道指出,连 Over 12 million premature babies are born each year worldwide. Sudden premature infants suddenly transferred from the warm mother’s uterus to the neonatal intensive care unit (neonatal intensive care unit, NICU) to receive the necessary rescue and treatment, the implementation of many invasive care operations, resulting in painful experience. Studies have shown that ~ ([1]), preterm infants less than 29 weeks gestational age undergo 300 or more painful maneuvers during their NICU stay of 3 months, such as heel bleeding, arteriovenous puncture, various injections, trachea Intubation, suction, PICC, fundus examination, etc., have reported that even