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目的 探讨E—CD在喉癌组织的表达与极其意义。方法 通过免疫组织化学和计算机图像分析技术,对E—CD在4例正常喉组织及40例喉癌和癌旁组织表达进行研究。结果 ①正常喉组织及癌旁组织E—CD表达强阳性,与喉癌组织差异显著。②不同分化程度的癌组织,其阳性表达呈明显差异。结论 E—CD免疫组化染色可作为判定喉癌细胞分化程度的一个重要的生物学指标。
Objective To investigate the expression of E-CD in laryngeal carcinoma and its significance. Methods The expression of E-CD in 4 cases of normal laryngeal tissue and 40 cases of laryngeal carcinoma and paraneoplastic tissues was studied by immunohistochemistry and computer image analysis. Results ① The positive expression of E-CD in normal laryngeal tissues and paracancerous tissues was significantly different from that in laryngeal carcinoma. ② different degrees of differentiation of cancer, the positive expression was significantly different. Conclusion E-CD immunohistochemical staining can be used as an important biological indicator to determine the degree of differentiation of laryngeal cancer cells.