论文部分内容阅读
目的:观察中西医结合治疗老年晚期非小细胞肺癌的疗效。方法:选择老年晚期非小细胞肺癌91例,随机分为对照组45例和观察组46例。对照组采用多西他赛联合顺铂治疗,观察组在对照组治疗基础上加用中药益肺饮治疗。比较两组近期疗效、生活质量、骨髓造血功能及肝肾功能变化情况。结果:观察组总控制率非常显著高于对照组(P<0.01),生活质量改善率显著高于对照组(P<0.05)。治疗前,两组血小板计数(PLT)、血红蛋白(Hb)、白细胞计数(WBC)水平比较,差异不显著(P>0.05);治疗后,两组PLT、Hb、WBC水平均显著低于治疗前(P<0.05),观察组PLT、Hb、WBC水平显著高于对照组治疗后(P<0.05)。治疗前,两组谷丙转氨酶(ALT)、谷草转氨酶(AST)、血尿素氮(BUN)、肌酐(Cr)异常比例比较,差异不显著(P>0.05)。治疗后,对照组ALT、AST、BUN、Cr异常比例均显著高于治疗前(P<0.05);观察组ALT、AST、BUN、Cr异常比例均高于治疗前,但差异不显著(P>0.05);观察组ALT、AST、BUN异常比例显著低于对照组治疗后(P<0.05)。结论:中西医结合治疗老年晚期非小细胞肺癌疗效优于单纯西药治疗。
Objective: To observe the effect of integrated traditional Chinese and western medicine on senile advanced non-small cell lung cancer. Methods: 91 elderly patients with advanced non-small cell lung cancer were randomly divided into control group (n = 45) and observation group (n = 46). The control group was treated with docetaxel and cisplatin, and the observation group was treated with Chinese medicine Yifei Yin on the basis of the control group. The curative effect, quality of life, bone marrow hematopoietic function and liver and kidney function were compared between the two groups. Results: The total control rate in observation group was significantly higher than that in control group (P <0.01), and the quality of life improvement rate was significantly higher than that in control group (P <0.05). Before treatment, the levels of PLT, Hb and WBC were not significantly different between the two groups (P> 0.05). After treatment, the levels of PLT, Hb and WBC in both groups were significantly lower than those before treatment (P <0.05). The levels of PLT, Hb and WBC in the observation group were significantly higher than those in the control group after treatment (P <0.05). Before treatment, the differences of ALT, AST, BUN and Cr between the two groups showed no significant difference (P> 0.05). After treatment, the abnormal proportion of ALT, AST, BUN and Cr in the control group was significantly higher than that before treatment (P <0.05). The abnormal proportion of ALT, AST, BUN and Cr in the observation group was higher than that before treatment, but the difference was not significant (P> 0.05). The abnormal proportion of ALT, AST and BUN in the observation group was significantly lower than that in the control group after treatment (P <0.05). Conclusion: Therapeutic effect of integrated traditional Chinese and western medicine on elderly advanced non-small cell lung cancer is better than western medicine alone.