【摘 要】
：
A selenium-modified hyaluronic acid(HA) compound(SeHA) was synthesized as a mimic of glutathione peroxidase(GPX). IR and NMR spectra of SeHA predict that the -C
【机 构】
：
College of life Science
论文部分内容阅读
A selenium-modified hyaluronic acid(HA) compound(SeHA) was synthesized as a mimic of glutathione peroxidase(GPX). IR and NMR spectra of SeHA predict that the -CH2OH group of the N-acetyl-D-glucosamine in HA was modified by group -SeH. There are averagely 152 -SeH groups in one SeHA molecule. The GPX activities are 103.88, 32.15 and 152.71 U/μmol, respectively, when the substrates were H2O2, BuOOH and CuOOH. Ping-pong mechanism was observed in the steady-state kinetic studies of the reactive oxygen species(ROS) consuming reaction. Result of reactions of SeHA with free radical capturer 2,6-di-tert-butyl-4-methylphenol(BHT) shows that the catalysis is based on a non-free radical-mechanism and the SeHA can not be inhibited by iodoacetate, an enzyme inhibitor.
其他文献
AIM: To assess the efficacy of premedicaton with pronase or N-acetylcysteine (NAC) at 20 min before upper gastrointestinal (UGI) endoscopy and to determine whet
Background lcariine is a flavonoid isolated from a traditional Chinese medicine Epimedium pubescens and is the main active compound of it. Recently, Epimedium p
To alert clinicians to a potential novel adverse drug effect of interferonβ 1a, we herein report a patient with relapsing-remitting multiple sclerosis who deve
Background Congenital long QT syndrome (LQTS) is an inherited ion channel disorder resulting in abnormal cardiac repolarization that can cause syncope and sudde
Background In a previous study, we have verified that CXCR4 expression is correlated with tumor aggressive progression and poor prognosis in patients with epith
AIM: To investigate the histopathological and geneticdifferences between polypoid growth (PG) and nonpolypoid growth (NPG) submucosal invasive colorectal carcin
从20世纪60年代开始,高效液相色谱法经过了实验和发展快速的应用时期.在目前的理论时间方面,已经得到了进一步的完善.如在医药检验、生命科学、药物研究、环保调查等等方面,
目的 对番禺区2005～2010年学校报告的突发公共卫生事件的流行病学特征进行分析,为预防、控制及有效处理突发公共卫生事件提供科学依据.方法 应用流行病学方法,对番禺区突发公
Objective: To establish a rabbit model of transplanted endometrial carcinoma with lymph node metastasis and observe its magnetic resonance imaging (MRI) feature
随着事业单位新会计制度的实行,对于高职院校的会计信息质量要求越来越高,特别是高职院校的发展已经走上了快车道,相对应的学校内部控制制度也就需要完善。本文通过分析了高