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背景与目的:脑胶质瘤占所有颅内肿瘤的一半左右,且好发于中青年人,对家庭和社会影响较大。本文总结脑胶质瘤手术治疗效果并探讨影响预后的因素。方法:回顾性分析我院近5年来手术治疗的脑胶质瘤患者病例资料并随访,对手术效果及预后行单、多因素综合分析。结果:显微手术治疗146例患者,男性77例,女性69例;年龄7～80岁,平均38.6岁;低级别胶质瘤(LGG)74例,高级别胶质瘤(HGG)72例,全切和大部切除117例,部分切除和活检29例,无手术死亡。术前、术后平均KPS为63.1、81.5分,术后平均升高18.4分,术后复发51例;获得完整随访资料71例,男性42例,女性29例;全切、次全切、部分切除加活检例数分别为21、35、15,共死亡29例,死亡比例40岁以下9/38,40岁及以上20/33;LGG8/36,HGG21/35。结论:年龄、肿瘤级别、肿瘤切除程度、术前术后KPS及放化疗与胶质瘤患者预后密切相关;年龄、肿瘤级别是预后的最危险因素,术后KPS及肿瘤切除程度与患者预后正相关。
Background and Objective: Glioma accounts for about half of all intracranial tumors, and occurs in young and middle-aged people, affecting the family and society more. This article summarizes the surgical treatment of glioma and explore the factors that affect the prognosis. Methods: The clinical data of patients with glioma surgically treated in our hospital during the past 5 years were retrospectively analyzed and followed up. The results of surgery and prognosis were analyzed by single factor and multifactorial analysis. Results: Microsurgical treatment of 146 patients, 77 males and 69 females; aged 7 to 80 years, mean 38.6 years; 74 cases of low grade glioma (LGG), 72 cases of high grade glioma (HGG) Total resection and partial resection in 117 cases, partial resection and biopsy in 29 cases, no operative death. Preoperative and postoperative mean KPS was 63.1, 81.5 points, postoperative average increased 18.4 points, postoperative recurrence in 51 cases; obtained complete follow-up information 71 cases, 42 males and 29 females; whole, subtotal, part The number of resection and biopsy were 21, 35 and 15, respectively, with 29 deaths, the death rate was 9/38 years old and 40 years old and 40/40 years old and above; LGG8 / 36 and HGG21 / 35. Conclusions: Age, tumor grade, tumor resection degree, preoperative and postoperative KPS and radiotherapy and chemotherapy are closely related to prognosis of glioma patients. Age and tumor grade are the most risk factors for prognosis. Postoperative KPS and tumor resection degree are correlated with prognosis Related.