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目的 :比较吸入双倍剂量二丙酸倍氯米松 (BDP)和吸入单剂量 BDP加小剂量茶碱对哮喘的作用。方法 :吸入单剂量 BDP40 0 μg/ d,连续 2 8d后症状不能控制者 ,测第 1秒用力呼气量 (FEV1 )。增加 BDP到 80 0 μg/ d或增加用氨茶碱 6 0 0 mg/ d后 ,第 7天、2 8天分别测峰值呼气流速 (PEF)、第 1 s用力呼气容积。结果 :两组 PEF7d后均有改善 ,统计学无显著性差异。FEV1 2 8天后均有明显增加 ,有显著性差异 (P<0 .0 1 )。结论 :对单剂量 BDP吸入治疗不能控制的哮喘患者 ,加用小剂量茶碱可替代增加吸入激素量来控制哮喘
OBJECTIVE: To compare the effects of inhaled double dose of beclomethasone dipropionate (BDP) and single dose of BDP plus a small dose of theophylline on asthma. Methods: Single dose of BDP40 0 μg / d was inhaled continuously for 28 days, and the first second forced expiratory volume (FEV1) was measured. The peak expiratory flow (PEF) and forced expiratory volume at 1 s were measured on the 7th day and the 28th day after increasing BDP to 80 0 μg / d or increasing aminophylline 600 mg / d. Results: Both PEF7d after the two groups have improved, no statistically significant difference. FEV1 2 8 days after a significant increase, a significant difference (P <0.01). Conclusion: A single dose of BDP inhalation therapy for uncontrollable asthma patients, plus a small dose of theophylline can be used instead of increasing the amount of inhaled corticosteroids to control asthma