自从1967年抗真菌的唑类化合物克霉唑和咪康唑问世并显示出实用价值以来,在以往12年内,已开发了多种此类药物,结果使皮肤真菌病及阴道真菌感染的治疗发生了引人注目的变化。唑类除了广谱的抗真菌活性外,还显示出特殊的皮肤和粘膜适应性,其很强的抗真菌活性使治疗真菌病的疗程显著缩短,并减少了复发。许多唑类衍生物局部使用、口服和非胃肠道给药均呈现抗真菌活性。全身性给药后, Since the antifungal azoles clotrimazole and miconazole appeared in 1967 and have shown practical value, many such drugs have been developed over the past 12 years, resulting in the treatment of dermatophytosis and vaginal fungal infections Notable changes. In addition to the broad spectrum of antifungal activity, azoles exhibit specific skin and mucosal adaptations. Their strong antifungal activity significantly shortens the course of treatment for fungal diseases and reduces recurrence. Many azole derivatives are topically applied, and both oral and parenteral administration exhibit antifungal activity. After systemic administration,