【摘 要】
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The worldwide outbreak of COVID-19 since December 2019 has caused great challenges to health organizations,and brought tremendous impact on the global economy.There have been over 62.3 million confirmed infection cases and 1.4 million deaths reported unti
【机 构】
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Shenyang National Laboratory for Materials Science,Northeastern University,Shenyang,110819,China;Key
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The worldwide outbreak of COVID-19 since December 2019 has caused great challenges to health organizations,and brought tremendous impact on the global economy.There have been over 62.3 million confirmed infection cases and 1.4 million deaths reported until now(December 1 st,2020),and the numbers are still growing[1].Although not as influential as COVID-19,the other two large pandemics,severe acute respiratory syndrome(SARS,outbroke in 2002)and Middle East respiratory syndrome(MERS,outbroke in 2012),were also caused by coronaviruses and resulted in severe public health and economic crises in several countries[2,3].Accompanied by the globalization,the highly connected human society through air travel and conventions offers conve-nience for the rapid spreading of viruses.Moreover,the occurrence of undetected viruses and their high spontaneous mutation rate challenge the cognitive process and the development of antiviral agents.In this view,the development of broad-spectrum antiviral strategies for prevention and control of viral transmission is of great importance for protecting our human society.
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