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目的比较不同体重指数(BMI)在白血病发病风险中的相关性。方法在Pub Med、Web of Science、万方数据库、中国知网、中国生物医学文献等数据库中,检索从2000年1月至2015年7月发表的不同BMI与白血病发病关系的病例对照研究。根据纳入标准和排除标准进行资料的提取,并对纳入的病例对照研究进行质量评价,采用Rev Man5.3软件对其进行Meta分析。结果共有四个病例对照研究纳入本Meta分析,其文献质量的评分均为4分以上,其中,白血病患者共2 681例(病例组),非白血病及相关肿瘤的其他患者共7 389例(对照组)。Meta分析显示,低BMl组的合并效应量OR=0.84[95%CI(0.62~1.13),P=0.26],超重组的合并效应量OR=0.93[95%CI(0.72~1.20),P=0.59],肥胖组的合并效应量OR=1.38[95%CI(0.96~2.00),P=0.08]。结论 BMI与白血病的发病风险呈正相关,提示低BMI可能是白血病发病的保护性因素,而肥胖可能是白血病发病的危险因素。
Objective To compare the association of different body mass index (BMI) in the risk of leukemia. METHODS: A case-control study of the relationship between different BMI and leukemia published from January 2000 to July 2015 was searched in Pub Med, Web of Science, Wanfang Database, China HowNet, and China Biomedical Literature. According to the inclusion criteria and exclusion criteria, the data were extracted, quality of the included case-control studies was evaluated, and Meta analysis was performed using Rev Man5.3 software. Results A total of four case-control studies were included in this meta-analysis. The scores of their literature quality were all over 4 points, of which 2 681 were leukemia patients (case group) and 7 389 were non-leukemia and other cancer-related patients (controls). group). Meta-analysis showed that the combined effect of low BM1 group OR = 0.84 [95% CI (0.62 ~ 1.13), P = 0.26], the combined effect of overweight OR = 0.93 [95% CI (0.72 ~ 1.20), P = 0.59], the combined effect of obese group OR = 1.38 [95% CI (0.96-2.00), P = 0.08]. Conclusions BMI is positively correlated with the risk of leukemia, suggesting that low BMI may be a protective factor for leukemia, and obesity may be a risk factor for leukemia.